Methylation Ltd. provides innovative reagents and kits for researchers working on DNA methylation and with DNA methyltransferases. Methylation Ltd’s lead technology to examine methylation in vivo is the ICM Assay Kits. These kits use aza-dC to track endogenous methylation enzymes (DNA methyltransferases or DNMTs) on specific genes inside tumour cells. Methylation Ltd also has in vitro assay kits for DNMT binding to DNA (SDSK+) as well as antibodies, DNA targets and drugs used in hypomethylation studies.

• ICM Kits for DNMT - DNMT isoform specific kits that measure endogenous binding of DNMT to genomic DNA. The method is antibody based with each kit optimised for a specific DNMT type
• Purified DNMT isoforms – overexpressed and purified to homogeneity
• Antibodies to DNMT isoforms – to be used in ICM Kits for western blotting and other specified applications
• Drugs for hypomethylation studies – 5 aza-2’-deoxycytidine and 5 aza-2’cytidine
• Human DNA and control DNA - substituted with aza-cytosine for use in DNA binding experiments involving DNMT. aza-dC substituted and control genomic DNA are also available
• Reagents for the ICM kits